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or a metabolic precursor or a metabolite thereof, wherein R moieties at the 5 if present, 8, 9 and 14 positions respectively are in the , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , or , , , configurations, wherein R10A, R10B, R10C, R10D and R10E respectively are in the , , , , , or , configurations, wherein, each R, R, R, R, R, R, R, R10A, R10B, R10C, R10D and R10E independently are H, OH, ORPR, SRPR, N RPR, O Si R, CHO, CHS, CN, SCN, NO, NH, COOH, OSO H, OPO H, an ester, a thioester, a thionoester, a phosphoester, a phosphothioester, a phosphonoester, a phosphiniester, a sulfite ester, a sulfate ester, an amide, an amino acid, a peptide, an ether, a thioether, an acyl group, a thioacyl group, a carbonate, a carbamate, a halogen, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl moiety, an optionally substituted heteroaryl moiety, an optionally substituted heterocycle, an optionally substituted monosaccharide, an optionally substituted oligosaccharide, a nucleoside, a nucleotide, an oligonucleotide, a polymer, or, one more of R, R, R, R, R, R, R, R10A, R10B, R10C, R10D and R10E are O, S, N OH, CH, CH CH, or an independently selected spiro ring and the hydrogen atom or the second variable group that is bonded to the same carbon atom is absent, or, one or more of two adjacent R R, R, R10A, R10B, R10C, R10D and R10E comprise an independently selected epoxide, acetal, a thioacetal, ketal or thioketal; R is C R, C R C R, C R C R C R, C R O C R, C R S C R, C R NRPR C R, O, O C R, S, S C R, NRPR or NRPR C R; R and R independently are C R, C R C R, O, O C R, S, S C R, NRPR or NRPR C R, or one or both of R or R independently are absent, leaving a 5 membered ring; R independently is C alkyl; and RPR independently is H or a protecting group how long after doxycycline can i have sex Clin Plast Surg 47 1 6

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